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Selective non zinc binding inhibitors of MMP13 |
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| Authors: | De Savi Chris Morley Andrew D Ting Attilla Nash Ian Karabelas Kostas Wood Christine M James Michael Norris Stephen J Karoutchi Galith Rankine Neil Hamlin Gordon Macfaul Philip A Ryan David Baker Sarah V Hargreaves David Gerhardt Stefan |
| Institution: | AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK |
| Abstract: | Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom. |
| Keywords: | MMP13 Selectivity Non zinc binder Lead Generation |
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