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2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus |
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| Authors: | Ali Abdelselam Cablewski Teresa Francis Craig L Ganguly Ashit K Sargent Roger M Sawutz David G Winzenberg Kevin N |
| Institution: | a CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, VIC 3168, Australia b Merck Research Laboratories, Merck & Co., 2015 Galloping Hill Road, Kenilworth, NJ 07033-1300, USA c Intervet Australia Pty Ltd, 26 Artisan Road, Seven Hills, NSW 2147, Australia |
| Abstract: | A series of 2-phenylimidazo1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD99 values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. |
| Keywords: | Imidazo[1 2-b]pyridazine Anthelmintic Haemonchus contortus |
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