Ommatidial development in Drosophila eye disc fragments |
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| Authors: | R M Lebovitz D F Ready |
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| Institution: | 1. Division of Cell Biology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan;2. Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan;1. Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA;2. Committee on Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, IL 60637, USA;3. Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA;1. Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, 13009 Marseille, France;2. Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France;1. Institute of Molecular Life Sciences, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland;2. Digital Imaging Research Centre, Faculty of Science, Engineering and Computing, Kingston University, Kingston-upon-Thames KT1 2EE, UK;3. Institute of Applied Simulations, Zürich University of Applied Sciences, Einsiedlerstrasse 31a, 8820 Wädenswil, Switzerland;4. SIB Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015 Lausanne, Switzerland;5. Apoptosis and Proliferation Control Laboratory, Lincoln''s Inn Fields Laboratory, Francis Crick Institute, 44 Lincoln''s Inn Fields, London WC2A 3LY, UK;6. MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK |
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| Abstract: | We have tested the hypothesis that the leading edge of the growing Drosophila compound eye acts as a template that organizes unpatterned cells of the retinal epithelium into the accurate cellular mosaic of the eye. Unpatterned fragments of the epithelium, not containing the leading edge of the growing field, were transplanted into larval hosts. After hosts pupated, the implants were recovered; most contained ommatidia, demonstrating that the leading edge of the growing eye pattern is not required for its propagation. In a second set of experiments, implants were recovered before hosts pupated and examined for ommatidia using a monoclonal antibody. These implants likewise differentiated ommatidia and the temporal progress of retinal development in the implants mirrored that of normal development. A schedule of ommatidial development thus appears to be mapped onto the retinal epithelium in advance of the leading edge. |
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