Juvenile hormone acid synthesis and HMG-CoA reductase activity in corpora allata of Manduca sexta prepupae |
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Institution: | 1. Institute for Developmental Biochemistry, Medical School, University of Göttingen, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany;2. Department of Nonlinear Dynamics, Max Planck Institute for Dynamics and Self-Organisation, Faculty of Physics, Bernstein Center for Computational Neuroscience, University of Göttingen, Am Faßberg 17, 37077 Göttingen, Germany |
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Abstract: | Corpora allata (CA) of last instar larvae of Manduca sexta switch from juvenile hormone (JH) to JH acid secretion just before the onset of wandering behavior. JH acid secretion peaked during the prepupal period and ceased prior to pupal ecdysis. HMG-CoA reductase activity also peaked during the prepupal period and then declined. However, substantial enzyme activity was present in pupal and pharate adult glands. Removal of the brain at the wandering stage caused a reduction in JH acid secretion by prepupal CA. The profile of HMG-CoA activity in CA of debrained larvae resembled that of sham-operated larvae except that the prepupal peak was smaller than in control larvae. Addition of brain extracts to CA maintained in vitro neither stimulated not inhibited JH acid secretion and HMG-CoA reductase activity. It is suggested that the brain regulates CA activity in post-wandering stages via intact nerves. |
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