A four compartment linear mammillary model |
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| Institution: | 1. LQTC Laboratory, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil;2. NMR Laboratory, Department of Chemistry, Federal University of Paraná, Paraná, Curitiba, Brazil;1. Drug Product Science and Technology, Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, United States;2. Analytical & Bioanalytical Development, Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, United States |
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| Abstract: | Studies are made for a four compartment model in which the central compartment is connected reversibly to three other compartments and the elimination occurs from the central compartment only. Identification of different distribution rate constants is made, with concentrations of drug in the central compartment at different times of observation being known. The solution depends on an optimization method in which the different unknowns are reduced to single variable with the help of Archimedes spiral. Thus, the solution requires the global minimum of a functional of single variable. Results are compared with those obtained by the generalized least square method. |
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