| 4-羟基苯并恶唑-2-酮对四氯化碳致小鼠急性肝损伤保护作用 |
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| 引用本文： | 祁平,樊惠,刘林,林军.4-羟基苯并恶唑-2-酮对四氯化碳致小鼠急性肝损伤保护作用[J].蛇志,2012,24(1):5-7,10. |
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| 作者姓名： | 祁平 樊惠 刘林 林军 |
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| 作者单位： | 广西医科大学药理学教研室,广西南宁,530021 |
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| 基金项目： | 广西自然基金资助项目(编号2009AM4019) |
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| 摘 要： | 日的研究4一羟基苯并恶唑-2-酮（4-hydroxy-2-benzoxazolone，HBOA）对四氯化碳所致小鼠急性肝损伤的保护作用，并探讨其疗效机制。方法采用腹腔注射四氯化碳（carbonte trachloride，cch）制备小鼠急性肝损伤模型，HBOA灌胃给药，检测小鼠血清中的乳酸脱氢酶（LDH）活性以及肝组织中过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）含量，并用免疫组化法观察肿瘤坏死因子（TNF-a）的表达情况。结果HBOA能明显降低CCh致急性肝损伤小鼠血清LDH活性，同时升高肝组织中CAT、GSH-Px的活性并降低肝组织中TNF-a的表达。结论HBOA对CCh所致小鼠急性肝损伤有一定的保护作用。
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| 关 键 词： | 4-羟基苯并恶唑-2-酮 急性肝损伤 CCl4 |
Protective effect of 4-Hydroxy-2-benzoxazolone against acute liver injury in mice |
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| QI Ping
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FAN Hui
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LIU Lin
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LIN Jun.Protective effect of 4-Hydroxy-2-benzoxazolone against acute liver injury in mice[J].Journal of Snake,2012,24(1):5-7,10. |
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| Authors: | QI Ping FAN Hui LIU Lin LIN Jun |
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| Institution: | (Department of Pharmacology,Guangxi Medical University,Nanning,Guangxi,530021,China) |
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| Abstract: | Objective To study the protective effect of 4-Hydroxy-2-benzoxazolone(HBOA) against liver injury induced by carbon tetrachloride(CCl4) in mice.Methods The acute liver injury model was prepared by the intraperitoneal injection of carbon tetrachloride.The levels of LDH in serum and levels of CAT,GSH-Px in liver tissue were measured and the expression of TNF-α were observed in order to evaluate the protective effects of HBOA.Results Compared with control group,the levels of serum LDH and the expression of TNF-α in liver tissue were decreased significantly and the levels of CAT,GSH-Px in liver tissue were increased obviously.Conclusion HBOA has protective effects against acute hepatic injury induced by CCl4 in mice. |
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| Keywords: | 4-Hydroxy-2-benzoxazolone Acute liver injury CCl4 |
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