Activation of red cell Ca2(+)-activated K+ channel by Ca2+ involves a temperature-dependent step |
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Authors: | L Varecka E Peterajová |
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Affiliation: | Mental Health Research Center of the Medical Bionics Institute, Psychiatric Hospital, Pezinok, Czechoslovakia. |
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Abstract: | We found that vanadate-induced 45Ca2+ uptake by red cells is maximal at 25 degrees C. At this temperature, the Cai-induced increase of the K+ permeability (the Gárdos effect) shows a lag (up to 8 min) which is not observed at 37 degrees C. This cannot be explained by the lack of availability of Ca2+ for the Ca2(+)-activated K+ channel, and suggests that its activation by Ca2+ is mediated by a temperature-dependent mechanism which remains unknown so far. The lag is not observed when the Gárdos effect was initiated by propranolol. This shows that the putative temperature-dependent step is different from chloride transport. |
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