Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes |
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Authors: | Zbytek Blazej Mysliwski Andrzej Slominski Andrzej Wortsman Jacobo Wei Edward T Mysliwska Jolanta |
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Affiliation: | Department of Histology and Immunology, Medical University of Gdansk, Poland. |
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Abstract: | CRH cutaneous expression is significantly enhanced after exposure to various stimuli (Physiol Rev 2000, 80;979-1020). We evaluated the effect of CRH on cytokine production in HaCaT keratinocytes, a cell line shown to express CRH receptors coupled to cAMP activation and calcium-dependent transmission pathways. It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11. It also inhibits production of IL-1beta and does not affect TNF-alpha production. Our results indicate that CRH function(s) during cutaneous stress may be mediated by differential effects on cytokine production. |
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Keywords: | Skin CRH Cytokines Keratinocytes |
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