Ketoconazole inhibits the conductance K+ induced by thyreoliberin (TRH) in GH3 cells |
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| Authors: | P Vacher P Mollard R Drouhault B Dufy |
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| Institution: | Laboratoire de Neurophysiologie, Unité Associée CNRS 1200, Université de Bordeaux. |
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| Abstract: | Ketoconazole an imidazole derivative used in clinical practice as an antifungal medicine interferes with the phospholipid dependent "second messenger" pathway. In this work we show that in the GH3 clonal cell line, ketoconazole (10 microM) inhibits part of the complex pattern of electrical activity induced by Thyrotropin-Releasing Hormone (TRH, 10 nM). The phase blocked by ketoconazole represents the Ca2+ -activated K+ conductance. |
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