4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70 |
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Authors: | Moffat D Davis P Hutchings M Davis J Berg D Batchelor M Johnson J O'Connell J Martin R Crabbe T Delgado J Perry M |
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Institution: | Celltech Therapeutics Limited, Slough, UK. dmoffat@celltech.co.uk |
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Abstract: | Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 70. |
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