Kinetics of channel formation of gramicidins A and B in phospholipid vesicle membranes. |
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| Authors: | P L Easton J F Hinton D K Newkirk |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville 72701. |
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| Abstract: | The thermal incorporation and channel formation of gramicidins A and B into phosphatidylcholine/phosphatidylglycerol large unilamellar vesicle membranes was studied using 23Na NMR. Delta H and delta S of activation for channel formation for gramicidin A are 11.8 kcal/mol and -11 e.u., respectively. For gramicidin B, delta H and delta S of activation are 14.6 kcal/mol and -4 e.u., respectively. Possible reasons for the differences in delta H and delta S of activation between the two analogues are discussed. |
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