Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans |
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Authors: | Norbeck Oscar Isa Adiba Pöhlmann Christoph Broliden Kristina Kasprowicz Victoria Bowness Paul Klenerman Paul Tolfvenstam Thomas |
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Affiliation: | Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08:03, SE-17177 Stockholm, Sweden. oscar.norbeck@cmm.ki.se |
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Abstract: | Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines. |
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