Generalised additive modelling approach to the fermentation process of glutamate |
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Authors: | Liu Chun-Bo Li Yun Pan Feng Shi Zhong-Ping |
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Affiliation: | a Key Laboratory of Advanced Process Control for Light Industry, Ministry of Education, Jiangnan University, Wuxi 214122, PR China b CSIRO Mathematics, Informatics and Statistics, Wembley, Western Australia 6913, Australia c Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR China |
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Abstract: | In this work, generalised additive models (GAMs) were used for the first time to model the fermentation of glutamate (Glu). It was found that three fermentation parameters fermentation time (T), dissolved oxygen (DO) and oxygen uptake rate (OUR) could capture 97% variance of the production of Glu during the fermentation process through a GAM model calibrated using online data from 15 fermentation experiments. This model was applied to investigate the individual and combined effects of T, DO and OUR on the production of Glu. The conditions to optimize the fermentation process were proposed based on the simulation study from this model. Results suggested that the production of Glu can reach a high level by controlling concentration levels of DO and OUR to the proposed optimization conditions during the fermentation process. The GAM approach therefore provides an alternative way to model and optimize the fermentation process of Glu. |
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Keywords: | Corynebacterium glutamicum Glutamate Fermentation Generalised additive models Optimization |
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