| 变构菌素生物合成基因簇的研究进展 |
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| 引用本文： | 李明,唐莉.变构菌素生物合成基因簇的研究进展[J].微生物学杂志,2011,31(3):87-91. |
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| 作者姓名： | 李明 唐莉 |
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| 作者单位： | 大连理工大学,分子药物中心,辽宁大连,116024 |
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| 摘 要： | 变构菌素是从Streptomyces griseochromogenes菌株中分离得到的第一个高选择性的蛋白磷酸化酶-1（PP-1）抑制剂。变构菌素及其衍生物在神经系统紊乱、代谢综合症、呼吸系统及相关疾病、免疫抑制、肿瘤治疗等诸多领域都有着广泛的应用前景,因而引起了人们对其生物合成途径的研究兴趣。介绍了近年来变构菌素生物合成途径的研究进展。
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| 关 键 词： | 变构菌素 蛋白磷酸酶 抑制 生物合成 基因簇 |
Advancement in Biosynthesis Gene Cluster of Tautomycetin |
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| LI Ming,TANG Li.Advancement in Biosynthesis Gene Cluster of Tautomycetin[J].Journal of Microbiology,2011,31(3):87-91. |
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| Authors: | LI Ming TANG Li |
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| Institution: | LI Ming,TANG Li(Ctr.of Molec.Pharm.,Dalian Uni.of Technol.,Dalian 116024) |
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| Abstract: | Tautomycetin(TTN)is a protein phosphorylase-1(PP-1) inhibitor with high selectivity firstly isolated from Streptomyces griseochromogenes strain.TTN and its bio-derivates have wide application prospects in disorder of nervous system,metabolic syndrome,respiratory diseases,immunosupression,and treatment of tumor and many other fields,which attracted people's research interest on its biosynthesis pathway accordingly.Advancement in recent TTN biosynthesis pathway study was introduced in this article. |
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| Keywords: | tautomycetin protein phosphorylase inhibition biosynthesis gene cluster |
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