N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor |
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| Authors: | Arora Jalaj Bordeleau Michel Dube Laurence Jarvie Keith Mazzocco Lucy Peragine Jack Tehim Ashok Egle Ian |
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| Institution: | NPS Pharmaceuticals, 6850 Goreway Dr., Mississauga, Ont., Canada L4V 1V7. |
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| Abstract: | A series of N-(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D(4) (hD(4)) and 5-HT(2A) receptors. Several compounds displayed selectivity for these receptors versus hD(2) and alpha(1) adrenergic receptors of over 500-fold. |
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