Study of a possible structural relationship between thymopoietin and the facteur thymique serique |
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Authors: | Karl Folkers Yieh-Ping Wan |
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Affiliation: | Institute for Biomedical Research The University of Texas at Austin Austin, Texas 78712 USA |
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Abstract: | Background peptide chemistry, and the known 49-amino acid sequence of thymopoietin and the known 9-amino acid sequence of the facteur thymique serique (FTS) allowed the concept that Arg49 of thymopoietin might be linked to Gln1 of FTS in a new 58-amino acid peptide in tissue. Cleavage between Arg49 and Gln50 adjacent to the unique Lys48-Arg49 moiety could liberate thymopoietin and the [H-Gln1]-FTS which could cyclize to FTS by the known reaction. In support of, rather than negating, this concept, synthetic FTS and the new dodecapeptide consisting of Val-Lys-Arg linked to the N-terminal of [H-Gln1]-FTS showed comparable immune stimulating activity, ; both peptides appeared more active than synthetic thymopoietin II. |
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