Selectivity in endocytosis of serum and cytosol proteins by macrophages in culture |
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Authors: | R.T. Dean |
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Affiliation: | Division of Cell Pathology MRC Clinical Research Centre Watford Road, Harrow, Middlesex HA1 3UJ UK |
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Abstract: | It was found that cultured mouse macrophages preferentially endocytose and degrade short half-life serum and cytosol proteins. With increasing duration of endocytosis, the components of longer half-life are increasingly endocytosed and degraded. The relevance of these observations to the selectivity of protein turnover is discussed. |
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