Effect of various prostaglandins on the release of arachidonic acid from cultured fibroblasts |
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Authors: | Sei-itsu Murota Tokiya Yokoi Ikuo Morita Yo Mori |
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Institution: | Department of Pharmacology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan |
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Abstract: | Effect of various prostaglandins on the release of arachidonic acid from 14C]arachidonic acid labeled fibroblasts was studied. Prostaglandin(PG) F2α was found to enhance the release of radioactive arachidonic acid from the cells. The stimulatory effect was dose dependent, and was greater than that of bradykinin. The active compounds can be ranked in potency for the release of arachidonic acid from the pre-labeled cells per cent of control: PGF2α(200.1%)>PGF1α (141.8%)>PGD2 (137.1%)>thromboxane B2 (113.7%)>PGE2 (109.4%). On the other hand, PGI2 showed a strong inhibitory effect on the arachidonic acid release from the pre-labeled cells (the value was only 69% of the control), while 6-ketoPGF1α, an end metabolite of PGI2, had no effect. |
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