In vitro reductive metabolism of N-nitrosodibenzylamine: Evidence for new reactive intermediates |
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Authors: | J Gal CD Estin BJ Moon |
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Institution: | Department of Pharmacology Division of Clinical Pharmacology: C237 School of Medicine University of Colorado Medical Center Denver, Colorado 80262 USA;School of Pharmacy University of Wisconsin Madison, Wisconsin 53706 USA |
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Abstract: | N-Nitrosodibenzylamine was incubated with rabbit-whole-liver homogenates. Gas-chromatographic and mass spectrometric analysis of the incubation extracts showed the formation of bibenzyl. This biotransformation is the result of a 2-electron reduction of the substrate to 1-hydroxy-2,2-dibenzylhydrazine, an unstable compound which breaks down to bibenzyl and nitrogen. It is suggested that such reductive metabolism may be involved in the generation of toxic metabolites of nitrosamines. |
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Keywords: | DBNA N-nitrosodibenzylamine |
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