Elasnin,a new human granulocyte elastase inhibitor produced by a strain of |
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Authors: | Satoshi Ōmura Hiroie Ohno Tsuneo Saheki Masakazu Yoshida Akira Nakagawa |
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Institution: | 1. Kitasato University Minato-ku, Tokyo 108, Japan;2. The Kitasato Institute, Minato-ku, Tokyo 108, Japan |
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Abstract: | Elasnin, a new human granulocyte elastase inhibitor, has been isolated from KM-2753. Elasnin is a neutral, lipophilic colorless and viscous oil (, , λmaxEtOH 291 nm (ε, 7760)). The molecular formula was C24H40O4 (M.W.: 392) as determined by its elemental analysis and mass spectrum. Elasnin inhibits markedly human granulocyte elastase, but is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain. |
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