Synthesis of 2, 3-dinor-PGFα metabolites |
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Authors: | John C Sih Sharon A Nash |
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Institution: | Experimental Chemistry Research, The Upjohn Company, Kalamazoo, Michigan 49001, USA |
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Abstract: | Thir report described the preparation of various 2,3-dinor-PGFα prostaglandins. Of particular importance is the synthesis of 2,3-dinor-15(S)-15-methyl PGF2α, the primary metabolite in the enzymatic degradation of 15(S)-15-methyl-PGF2α (1). Introduction of the three carbon β,γ-unsaturated carboxyl side chain was achieved in a one-step Wittig reaction. The 2,3-dinor structural assignments were established by carbon magnetic resonance (crm) spectroscopy. |
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