Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase |
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Authors: | Luu-The V |
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Affiliation: | Medical Research Council Group in Molecular Endocrinology, Medical Research Council Group, Oncology and Molecular Endocrinology Research Center, Laval University Hospital Center (CHUL) and Laval University, 2705 Laurier Boulevard, Sainte-Foy, Quebec, Canada G1V 4G2 |
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Abstract: | Androgens and estrogens are not only synthesized in the gonads but also in peripheral target tissues. Accordingly, recent molecular cloning has allowed us to identify multiple types of 17β-hydroxysteroid dehydrogenases (17β-HSD), the key and exclusive enzymes involved in the formation and inactivation of sex steroids. However, only one form, namely, type 3 17β-HSD, is responsible for pseudohermaphroditism in deficient boys. To date, seven human 17β-HSDs have been isolated and characterized. Although they catalyze substrates having a similar structure, 17β-HSDs have very low homology. In intact cells in culture, these enzymes catalyze the reaction in a unidirectional way — types 1, 3, 5 and 7 catalyze the reductive reaction, while types 2, 4 and 8 catalyze the oxidative reaction. It is noteworthy that rat type 6 17β-HSD also catalyzes the reaction in the oxidative direction. In this report, we analyze the different characteristics of the multiple types of human 17β-HSD. |
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Keywords: | Sex steroids Steroidogenesis 17β-Hydroxysteroid dehydrogenase |
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