Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis |
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| Authors: | Liam G Coulthard Jaclyn Costello Brent Robinson Ian A Shiels Stephen M Taylor Trent M Woodruff |
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| Affiliation: | (1) School of Biomedical Sciences, University of Queensland, Research Road, St. Lucia, Queensland, 4072, Australia |
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| Abstract: | Introduction Previously, secretory phospholipase A2 (sPLA2) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials without significant improvement of arthritic pathology. In this study, we compared the efficacy of a potent and orally active group IIa secretory phospholipase A2 inhibitor (sPLA2I) to conventional anti-arthritic agents; infliximab, leflunomide and prednisolone, in a rat model of antigen-induced arthritis. |
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