Application of <Emphasis Type="Italic">in vivo</Emphasis> micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Application of <Emphasis Type="Italic">in vivo</Emphasis> micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis

Authors:	Geetha Mohan Egon Perilli Julia S Kuliwaba Julia M Humphries Ian H Parkinson Nicola L Fazzalari

Institution:	(1) Bone and Joint Research Laboratory, Directorate of Surgical Pathology, SA Pathology and Hanson Institute, Frome Road, Adelaide, SA, 5000, Australia;(2) Discipline of Anatomy and Pathology, School of Medical Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia

Abstract:	Introduction Osteoarthritis (OA) is a complex, multifactorial joint disease affecting both the cartilage and the subchondral bone. Animal models of OA aid in the understanding of the pathogenesis of OA and testing suitable drugs for OA treatment. In this study we characterized the temporal changes in the tibial subchondral bone architecture in a rat model of low-dose monosodium iodoacetate (MIA)-induced OA using in vivo micro-computed tomography (CT).

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