GLUT 1-glucose transporter protein in adult and fetal mouse lung |
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Authors: | G Mantych U Devaskar D deMello S Devaskar |
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Affiliation: | Department of Pediatrics, St. Louis University School of Medicine, Mo. |
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Abstract: | We observed approximately 45-50 kD GLUT 1 protein in mouse lung homogenates and demonstrated a greater abundance in fetus compared to adult. In situ immunohistochemical analysis demonstrated GLUT 1 expression only in the perineural sheath of nerves. While the trapped fetal red blood cells expressed GLUT 1 abundantly, adult red blood cells were devoid of GLUT 1. No GLUT 1 was evident in fetal and adult lung alveolar and bronchiolar epithelial cells, vascular endothelial cells and the lung mesenchymal elements. Thus, GLUT 1 is not the major lung glucose transporter. |
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