CCR2-64I allele is associated with the progression of AIDS in a Han Chinese population |
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Authors: | Lidan Xu Yuandong Qiao Xuelong Zhang Haiming Sun Jingwei Wang Donglin Sun Yan Jin Yang Yu Feng Chen Jing Bai Hong Ling Kaili Wang Songbin Fu |
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Affiliation: | 1. Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China 2. Department of Microbiology, Harbin Medical University, Harbin, 150081, China 3. Heilongjiang Center for Disease Control and Prevention, Harbin, 150030, China 4. Bio-Pharmaceutical Key Laboratory of Heilongjiang Province, Laboratory of Medical Genetics, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, 150081, China
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Abstract: | It has been reported that the CCR5-Delta32, CCR2-64I and SDF1-3′A polymorphisms have protective effects against HIV-1 infection and can delay the progression of AIDS in European populations. The aim of this study was to investigate the associations of the three loci with HIV-1 infection and the progression of AIDS in the Han population of northern China. We recruited 78 HIV-1-seropositive individuals and 70 population-matched healthy controls from north China. PCR-RFLP was used to genotype these three polymorphisms in all samples. There were no significant differences in the frequencies of any allele between HIV-1-seropositive individuals and healthy controls. In cases, the associations between the three loci and CD4+ T-lymphocyte counts were not significant; however, there was a significant association between the genotype frequency of CCR2-64I and clinical category (P < 0.05). We have identified a potentially important role of CCR2-64I allele in AIDS progression in the northern Chinese population. Further studies are necessary to clarify the contribution of the CCR2-64I allele to the progression of AIDS for the relatively small sample size. |
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