Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population |
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Authors: | Hong Zhi Hua Wang Liqun Ren Zhiyang Shi Haiyan Peng Lunbiao Cui Genshan Ma Xingzhou Ye Yi Feng Chengxing Shen Xiangjun Zhai Chenyu Zhang Ke Zen Naifeng Liu |
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Affiliation: | 1. Department of Cardiology, ZhongDa Hospital, Southeast University, 87 Dingjiaqiao Road, 210009, Nanjing, China 2. Department of Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, 210009, Nanjing, China 3. Department of Biology, School of Life Science, Nanjing University, 210009, Nanjing, China
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Abstract: | Matrix metallopeptidase-9 (MMP-9) plays a pivotal role in vascular remodeling and development of atherosclerotic lesion. The potentially functional MMP-9 polymorphisms may contribute to the susceptibility of coronary artery disease (CAD). A case–control study composed of 762 CAD cases and 555 CAD-free controls was conducted in a Chinese population to investigate the association between the MMP-9 ?1562 C>T, R279Q, P574R and R668Q polymorphisms and CAD risk. It was found that the variant genotypes of R279Q, P574R and R668Q were associated with a non-significant decreased risk of CAD when compared with their wild-type genotypes, respectively, Furthermore, compared with those without any variant genotypes for these four nonsynonymouse loci, individuals carrying all four variant genotypes (?1562 CT/TT, 279 RQ/QQ, 574 PR/RR and 668 RQ/QQ) had a 51% decreased risk of CAD (adjusted OR = 0.49; 95% CI = 0.26–0.95, P = 0.033). Although no significant main effects were observed for MMP-9 ?1562 C>T locus on CAD risk, variant genotypes of ?1562 C>T were associated with a 2.53 increased risk of CAD in subjects with diabetes mellitus (DM) (95% CI = 1.18–5.45, P = 0.018). In CAD cases, variant genotypes of ?1562 C>T were associated with a significantly increased risk of MI (adjusted OR, 1.48, 95% CI, 1.01–2.20, P = 0.048). These findings suggest that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of CAD and ?1562 CT/TT genotypes may contribute to CAD in diabetics and MI in CAD patients. |
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