Asymmetric synthesis of novel pseudo-D-vinylcyclopropyl nucleosides bearing quaternary carbon as potential anti-herpesvirus agent |
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| Authors: | Park Ah-Young Moon Hyung Ryong Kim Kyung Ran Chun Moon Woo Jeong Lak Shin |
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| Institution: | College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Korea. |
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| Abstract: | Pseudo-D-vinylcyclopropyl nucleosides 10-12 bearing a quaternary carbon were designed and synthesized starting from (R)-epichlorohydrin using a tandem reaction of double alkylation and lactonization via oxirane-ring opening reaction, a Wittig reaction, and chemoselective reduction as potential anti-herpesvirus agent. |
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