Modulation of phospholipase A2 activity in zymogen granule membranes by GTP[S]; evidence for GTP-binding protein regulation |
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| Authors: | R P Rubin M Withiam-Leitch S G Laychock |
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| Institution: | Department of Pharmacology & Therapeutics, State University of New York, Buffalo 14214. |
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| Abstract: | In membranes associated with purified pancreatic zymogen granules, GTPS] elicited a concentration-dependent activation of phospholipase A2 (PLA2), which was converted to inhibition in the presence of added Ca2+. The GTP-binding protein inhibitor GDPS] blocked both the stimulatory and inhibitory actions of GTPS]. We conclude that in zymogen granule membranes GTP-binding proteins exert a dual regulation of PLA2 activity. |
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