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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS) |
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| Authors: | Cheshire David R Åberg Anders Andersson Gunilla M K Andrews Glen Beaton Haydn G Birkinshaw Timothy N Boughton-Smith Nigel Connolly Stephen Cook Tony R Cooper Anne Cooper Sally L Cox David Dixon John Gensmantel Nigel Hamley Peter J Harrison Richard Hartopp Paul Käck Helena Leeson Paul D Luker Timothy Mete Antonio Millichip Ian Nicholls David J Pimm Austen D St-Gallay Steve A Wallace Alan V |
| Affiliation: | a Department of Chemistry, AstraZeneca Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom b Department of Bioscience, AstraZeneca Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom c Department of Physical and Metabolic Sciences, AstraZeneca Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom d Discovery Chemistry, Pepparedsleden 1, 431 83 Mölndal, Sweden |
| Abstract: | By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8. |
| Keywords: | Nitric oxide Nitric oxide synthases Competitive iNOS inhibitors |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |