Cytochrome C phospholipid interaction: structural transitions associated with valency changes |
| |
| Authors: | A Azzi S Fleischer B Chance |
| |
| Affiliation: | 1. Johnson Research Foundation University of Pennsylvania USA;2. Department of Molecular Biology Vanderbilt University USA;1. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11-222, Palmerston North, New Zealand;1. Normandie Univ, UNILEHAVRE, FR 3038 CNRS, URCOM, 76600 Le Havre, France;2. University of Nouakchott, Faculty of Sciences and Technics, LCME, Nouakchott, Mauritania |
| |
| Abstract: | Cytochrome c is known to combine with phospholipids (1,2) and there is evidence that it also exists in the mitochondrial respiratory chain in close relationship with phospholipids (2,3).This study is concerned with structural transitions occurring in the cytochrome c-phospholipid complex when the valency of cytochrome c is changed.The fluorescent probe, 8-anilino-1-naphthalene sulfonic acid (ANS) has a quantum yield and a maximum emission wavelength that are sensitive to the polarity of its environment (4). It has been used to monitor changes of the structure of the cytochrome c-phospholipid complex, reflecting a polarity change at the ANS binding site. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
