A physico-chemical and biological study of novel chitosan-chloroquinoline derivative for biomedical applications |
| |
Authors: | Kumar Santosh Dutta P K Koh Joonseok |
| |
Institution: | a Department of Textile Engineering, Konkuk University, Seoul 143701, South Korea b Department of Chemistry, MN National Institute of Technology, Allahabad 211004, India |
| |
Abstract: | This paper describes an elegant cross-linking technique for the preparation of chitosan-chloroquinoline derivative by using a greener technique. Chitosan solution in aqueous acetic acid was treated with 2-chloroquinoline-3-carbaldehyde solution to form hydrogel; the resulting hydrogel was subjected to solvent exchange. Combining the results of FTIR and XRD confirmed that 2-chloroquinoline-3-carbaldehyde have been reacted to chitosan. The morphology of the derivative was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The thermal stability of the derivative was examined by thermogravimetric analysis (TGA). The photoluminescence (PL) spectra of chitosan-chloroquinoline derivative show red-shifted emission maximum. The microbiological screening has demonstrated the antimicrobial activity of the derivative against bacteria viz. Staphylococcus aureus, Escherichia coli and Candida albicans. The obtained results showed that the chitosan-chloroquinoline derivative might be a promising candidate for novel antimicrobial agents for biomedical applications. |
| |
Keywords: | Chitosan Chloroquinolindehyde Solvent exchange Antimicrobial activity |
本文献已被 ScienceDirect PubMed 等数据库收录! |