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Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein |
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| Authors: | Nosá?ová G Prisen?ňáková L Paulovi?ová E Capek P Matulová M Navarini L Liverani F Suggi |
| Institution: | a Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Sklabinska 26, 037 53 Martin, Slovakia b Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38 Bratislava, Slovakia c Illycaffè s.p.a., Research & Innovation, via Flavia, 110, I-34147 Trieste, Italy |
| Abstract: | A low molecular mass arabinogalactan-protein (AGP) composed of galactose and arabinose with a low protein content, isolated from the instant coffee powder of Coffea arabica beans, has been tested on antitussive (in vivo) and immunomodulating (ex vivo) activities. The results of antitussive tests revealed a significant dose dependant cough-suppressive effect of coffee AGP. It was observed 30 or 60 min after AGP administration and its efficacy lasted during the entire experiment course. Immunological tests showed that AGP affected some mediators of immunocompetent cells of immune system as TNF-α, IFN-γ and IL-2 cytokines. It seems that coffee AGP is a good inductor of both pro-inflammatory cytokines TNF-α and IFN-γ, however, less potent in TNF-α induction in comparison with that of β-d-glucan. Evident induction of TNF-α, IL-2 and IFN-γ cytokines, pro-TH1 polarization supports our conclusion about bio-immunological efficacy of AGP with an emphasis on the cellular immunity. |
| Keywords: | Coffea arabica Instant coffee Arabinogalactan-protein Antitussive activity Immunomodulating activity |
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