| 用单克隆抗体选择具有潜在流行病学意义的A/曼谷79—1流感病毒变异株 |
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| 引用本文： | 龚新昌,田淑芳,范瑞莲,杨冬荣,张珍,王秀平,朱既明.用单克隆抗体选择具有潜在流行病学意义的A/曼谷79—1流感病毒变异株[J].病毒学报,1985(2). |
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| 作者姓名： | 龚新昌 田淑芳 范瑞莲 杨冬荣 张珍 王秀平 朱既明 |
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| 作者单位： | 中国预防医学中心病毒学研究所
(龚新昌，田淑芳，范瑞莲，杨冬荣，张珍，王秀平)，中国预防医学中心病毒学研究所(朱既明) |
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| 摘 要： | 用甲3型流感病毒A/曼谷79-1血凝素特异的单克隆抗体,对我国从1979—1984年分离的45株H3N2病毒进行了抗原分析,并与用单克隆抗体选择的51株A/曼谷79-1变异株作了比较。发现后者同1979年以来我国流行的H3N2流感主流株高度相似。这证明,用单克隆抗体可选出有流行潜力的变异株。本文就通过单克隆抗体选择、提前获得甲型流感亚型内变种的可能性进行了讨论。
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| 关 键 词： | 抗原变异 单克隆抗体 H3N2甲型流感病毒 |
SELECTION OF A/BANGKOK/79-1 VARIANTS OF POTENTIAL EPIDEMIOLOGICAL SIGNIFICANCE WITH MONOCLONAL ANTIBODIES |
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| Gong Xinchang Tian Shufang Fang Ruiling Yang Dongrong Wang Xiuping Zhang Zhen Chu Chiming.SELECTION OF A/BANGKOK/79-1 VARIANTS OF POTENTIAL EPIDEMIOLOGICAL SIGNIFICANCE WITH MONOCLONAL ANTIBODIES[J].Chinese Journal of Virology,1985(2). |
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| Authors: | Gong Xinchang Tian Shufang Fang Ruiling Yang Dongrong Wang Xiuping Zhang Zhen Chu Chiming |
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| Abstract: | Forty-five strains of influenza viruses ( H3N2 ) isolated in China in 1979-1984 have been analysed with McAbs to A/Bangkok/79-1 hemagglutinin. Com-parsion with 51 of A/Bangkok/79-1 variants selected with McAbs we found that the prevalent epidemic strains in China since 1979 are highly homologous with some of the variants selected with McAbs.These results indicate that variants selected with McAbs have potential epidemiological significance The posibility for selection of variants of influenza A virus with McAb in the laboratory before their natural occurrence is discussed. |
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| Keywords: | H3N2 influenza A virus Antigenic variation Monoclonal antibody |
| 本文献已被 CNKI 等数据库收录！ |
