New bioactive aromatic compounds from Vismia guianensis |
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| Authors: | Seo E K Wani M C Wall M E Navarro H Mukherjee R Farnsworth N R Kinghorn A D |
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| Institution: | Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA. |
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| Abstract: | Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. |
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