The effect of oestradiol on the DNA synthesis in neonatal mouse uterus and cervix

Summary (³H)-Thymidine autoradiography was used to study the DNA synthesis in the stroma and epithelium in the uterus proper and the uterine cervix of neonatal mice treated with oestradiol. It was found that in the epithelium of the uterus proper the DNA synthesis is stimulated between 6 and 12 h after injection of oestradiol and decreases again at 18 h. In the stroma of the uterus proper the DNA synthesis is increased 18 h after oestradiol injection.In the epithelium and stroma of the uterine cervix the DNA synthesis decreases from 5 h and is strongly depressed 18 h after oestradiol treatment.This work has been supported by grants from the Norwegian Research Council for Science and the Humanities and from the Norwegian Cancer Society (Landsforeningen mot Kreft).