Synthesis and biological evaluation of novel lipid A antagonists |
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Authors: | Peri Francesco Marinzi Chiara Barath Marek Granucci Francesca Urbano Matteo Nicotra Francesco |
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Affiliation: | Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy. francesco.peri@unimib.it |
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Abstract: | A mimetic of Lipid A with a beta-N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its beta-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflammatory activity. |
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