The time-related subcellular distribution of chromium in the rat liver cell after intravenous administration of Na2 51CrO4 |
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Authors: | Sverre Lang»rd |
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Affiliation: | (1) Department of Occupational Medicine, Telemark Sentralsjukehus, 3900 Porsgrunn, Norway |
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Abstract: | After intravenous administration of Na2 51CrO4 to rats the subcellular distribution of51Cr was determined at different time intervals after dosage. A time-related compartment shift from the cytosol into the mitochondrial and nuclear fractions was demonstrated. Dialysis studies indicated a firmer binding of51Cr to the mitochondrial and nuclear fractions than to the cytosol. Indirect evidence is presented that reduction from CrVI to CrIII takes place primarily inside the mitochondria. The hypothesis is put forward that reduction from CrVI to CrIII may take place at any intracellular site where electron donors are available. Electron donors in the different intracellular organelles are discussed. |
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Keywords: | Chromates, distribution in the rat liver cell toxicity, of chromates in the rat liver cell subcellular distribution, of chromates in the rat liver cell chromate reduction, in the rat liver cell mitochondria, rat liver, and chromates electron donors, and chromate distribution in the rat liver cell liver, rat, and chromate distribution rat, liver cell distribution of chromates |
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