CFP: a web-server for constructing sequence-based protein conformational flexibility profiles |
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| Authors: | Igor B Kuznetsov Shalom Rackovsky |
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| Affiliation: | 1.Cancer Research Center, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA;2.Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA |
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| Abstract: | Many proteins contain conformationally flexible segments that undergo significant changes in the backbone conformation or completely lack awelldefined conformation. Previously, we have developed the generalized local propensity (GLP), a quantitative sequence-based measure of theprotein backbone flexibility. In this paper, we present the CFP (Conformational Flexibility Profile) webserver that constructs the GLP flexibilityprofile for a usersubmitted sequence and uses this profile to identify segments with high backbone flexibility. The statistical significance of aflexible sequence segment is assessed using the discrete scan statistics based on the density of flexible residues observed in this segment.AvailabilityCFP is publicly available at http://cfp.rit.albany.edu |
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| Keywords: | conformational variability protein backbone flexibility local propensity sequence |
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