Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai |
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Authors: | Y Koshihara T Neichi S Murota A Lao Y Fujimoto T Tatsuno |
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Affiliation: | 1. Station de Pathologie Végétale, INRA, 28 rue de Herrlisheim, 68021 Colmar, France;2. Laboratoire de Virologie, Institut de Biologie Moléculaire et Cellulaire du CNRS, 15 rue Descartes, 67084 Strasbourg, France |
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Abstract: | Three of four natural compounds, which are caffeic acid, eupatilin and 4'-demethyleupatilin, isolated from Chinese plant, Artemisia rubripes Nakai selectively inhibited 5-lipoxygenase of cultured mastocytoma cells. Half-inhibition doses (ID50) for caffeic acid, eupatilin and 4'-demethyleupatilin were 3.7, 14 and 18 X 10(-6) M, respectively. The inhibition by caffeic acid was non-competitive types. Prostaglandin synthase activities were little inhibited by eupatilin and 4'-demethyleupatilin, but rather stimulated by caffeic acid. The formation of leukotriene C4 and D4 by mast tumor cells was almost completely suppressed by these compounds at 10(-4) M. |
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Keywords: | Plant virus Tobamo virus RNA Cap structure Poly(A) |
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