In-depth analysis of proteomic and genomic fluctuations during the time course of human embryonic stem cells directed differentiation into beta cells |
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| Authors: | Bogdan Budnik Juerg Straubhaar John Neveu Dmitry Shvartsman |
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| Affiliation: | 1. Mass Spectrometry and Proteomics Resource Laboratory (MSPRL), FAS Division of Science, Harvard University, Cambridge, Massachusetts, USA;2. Informatics and Scientific Applications Group, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA;3. Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA |
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| Abstract: | |
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| Keywords: | beta cell (β-cell), cell signaling, chromogranin, insulin, integrin, laminin mass spectrometry (MS), multiomics, nano LC-MS/MS NKX6-1, pancreas pancreatic islet, phosphoproteomics, phosphorylation, protein dynamic, proteomics, signaling networks, single-cell RNA sequencing, stem cells, systems biology, Type 1 diabetes, Type 2 diabetes |
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