Alpha-adrenergic receptor blocking effect of Cleistanthus collinus (Roxb.) Benth. and Hook f. leaf extract on guinea pig isolated smooth muscle preparations |
| |
Authors: | Kumar M Ravindra Ramaswamy S Jayanthi M Raveendran R |
| |
Institution: | Department of Pharmacology, JIPMER, Pondicherry 605 006, India. |
| |
Abstract: | Aqueous extract of C. collinus leaves inhibited norepinephrine induced contraction in guinea pig vas deferens and aortic strip in a dose-dependent manner. Inhibition of acetylcholine induced contraction in ileum was dose independent. C. collinus extract per se had no effect on isolated guinea pig vas deferens and aortic strip, but inhibited norepinephrine induced contraction in a dose-dependent manner probably by its antagonist action on alpha-adrenergic receptor. It had inconsistent effect on guinea pig ileum in vitro preparation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|