Protein kinase affinity reagents based on a 5-aminoindazole scaffold |
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Authors: | Krishnamurty Ratika Brock Amanda M Maly Dustin J |
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Institution: | Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, United States. |
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Abstract: | Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures. |
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