| FSHR、LHR基因突变与多态对女性生殖的影响 |
| |
| 引用本文： | 周立花,李汶,卢光琇.FSHR、LHR基因突变与多态对女性生殖的影响[J].现代生物医学进展,2010,10(1). |
| |
| 作者姓名： | 周立花 李汶 卢光琇 |
| |
| 作者单位： | 1. 中南大学生殖与干细胞工程研究所,湖南,长沙,410087
2. 中南大学生殖与干细胞工程研究所,湖南,长沙,410087;中信湘雅生殖与遗传专科医院,湖南,长沙,4100087 |
| |
| 摘 要： | 卵泡刺激素(FSH)与黄体生成素(LH)促进性腺的发育和成熟、调节人类配子的产生,在生殖方面起着关键的作用。两受体(FSHR与LHR)的突变会导致生殖能力的改变,出现一系列临床症状,引起组织学,分子水平等多方面的变化,同时FSHR的多态性与卵巢反应性、女性的月经周期等许多方面相关。本文从多方面阐述FSHR与LHR对女性生殖的影响。
|
| 关 键 词： | FSHR LHR 突变 多态性 卵巢反应性 |
The Influence of Gene Mutations and Polymorphism of FSHR and LHR to the Female Reproduction |
| |
| ZHOU Li-hua,LI Wen,LU Guang-xiu.The Influence of Gene Mutations and Polymorphism of FSHR and LHR to the Female Reproduction[J].Progress in Modern Biomedicine,2010,10(1). |
| |
| Authors: | ZHOU Li-hua LI Wen LU Guang-xiu |
| |
| Institution: | ZHOU Li-hua1,LI Wen1,2,LU Guang-xiu1,2(1 Insistitute of Reproduction , Stem Cell Engineering,Central South University,Changsha,Hunan,410087,China,2 Reproductive , Genetic Hospital of Citic-Xiangya,Hunnan,China) |
| |
| Abstract: | FSH and LH are the central hormones of humanre production,necessary for gonadal development and maturation at puberty and for gamete production during the fertile phase of life.The gene mutations of FSHR and LHR have the influence to the human reproduction,leading to many changes in clinical symptoms,histology and molecular level.The polymorphism of FSHR and LHR also have a role in regulating the ovarian reaction to hormone in controlled ovarian hyperstimulation,and change the menstrual cycle as well.Here w... |
| |
| Keywords: | FSHR LHR gene mutation polymorphism ovarian reaction |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
