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Structure of d-amino acid oxidase: new insights from an old enzyme |
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| Authors: | Andrea Mattevi Maria A Vanoni Bruno Curti |
| Institution: | aDipartimento di Genetica e Microbiologia, Universitá di Pavia, Via Abbiategrasso 207, 27100 Pavia, Italy;bDipartimento di Fisiologia e Biochimica Generali, Universitá di Milano, Via Celoria 26, 20133, Milano, Italy |
| Abstract: | d-amino acid oxidase is the prototype of flavin-dependent oxidases. The recent resolution of its 3D structure has provided an explanation for several of its properties and has led to a substantial revision of the mechanism of d-amino acid dehydrogenation, with significant implications for the general uderstanding of flavin-dependent catalysis |
| Keywords: | Abbreviations: CoA coenzyme A DAAO D-amino acid oxidase FAD flavin adenine dinucleotide FCB2 flavocytochrome b2 iTrp imino tryptophan |
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