|
|||||
|
|
Study of peptide degradation in the serum by 1H-NMR |
|
| Authors: | O L Isakova N F Sepetov Zh D Bespalova V N Bushuev V A Vinogradov |
| Abstract: | Enzymatic degradation of hexapeptide Tyr-D-Ala-Gly-Phe-Leu-Arg in human serum has been investigated by 1H-NMR spectroscopy, and its pathways are suggested. Its final degradation products, tetra- and pentapeptide, are shown to be stable in human serum for several hours. The NMR spectroscopy application for pharmacokinetic studies is substantiated. |
| Keywords: | |