Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine |
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| Authors: | H Suzuki N D Christofides T E Adrian M Chretien N G Seidah J M Polak S R Bloom |
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| Institution: | 1. Departments of Medicine and Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 0HS, U.K.;2. Laboratories of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada H2W 1R7 |
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| Abstract: | The developmental profile of the concentration of a novel pituitary protein (7B2) was studied immunochemically in the human gastrointestinal tract from 12 weeks of gestation to 4 months after birth and was compared to the distribution in the adult. 7B2-like immunoreactivity (IR-7B2) was detected in all segments studied, but no gross changes were seen through fetal life. At term higher concentrations of IR-7B2 were found in the duodenum and the antrum, which is similar to the distribution of adult man. Gel permeation chromatography revealed that the main peak of 7B2 immunoreactivity in the fetal intestinal extract eluted with a Kav of 0.3. Similar elution profiles were also observed in extracts of human adult intestine. |
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| Keywords: | ontogeny gastrointestinal tract 7B2 radioimmunoassay |
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