| 骨骼肌收缩模式对p38／Akt磷酸化水平的影响 |
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| 引用本文： | Li H,Jiao B,Yu ZB,Chen ZQ. 骨骼肌收缩模式对p38／Akt磷酸化水平的影响[J]. 中国应用生理学杂志, 2011, 27(4): 500-504 |
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| 作者姓名： | Li H Jiao B Yu ZB Chen ZQ |
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| 作者单位： | 南京军区福州总医院医学影像科;第四军医大学航空航天生理教研室; |
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| 基金项目： | 国家自然科学基金资助课题(305000252) |
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| 摘 要： | 目的：骨骼肌收缩可能通过非胰岛素依赖的途径促进葡萄糖摄取,而p38与Akt可能是其中起重要作用的分子。本文研究骨骼肌不同收缩模式对上述信号分子磷酸化的影响,从而探讨有效降低血糖的运动方式。方法：采用离体比目鱼肌肌条灌流技术及Western blot检测方法,研究不同模式的收缩对骨骼肌p38、Akt磷酸化水平的影响。结果：5min10％DC（dutycycle负荷率）和5min1％Dc的收缩模式可分别使p38的磷酸化较对照组增加30％和34％,是激活p38的适宜刺激。但对Akt的磷酸化水平没有影响。结论：低强度有氧运动可以更好地激活038,但不能有效激活Akt。
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| 关 键 词： | 强直收缩 p38 Akt 葡萄糖摄取 |
The influence of contraction modes on the phosphorylation of p38/Akt |
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| Li Hui,Jiao Bo,Yu Zhi-Bin,Chen Zi-Qian. The influence of contraction modes on the phosphorylation of p38/Akt[J]. Chinese journal of applied physiology, 2011, 27(4): 500-504 |
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| Authors: | Li Hui Jiao Bo Yu Zhi-Bin Chen Zi-Qian |
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| Affiliation: | LI Hui1,JIAO Bo2,YU Zhi-bin2,CHEN Zi-qian1(1.Fuzhou General Hospital of PLA,Fuzhou 350025,2.Department of Aerospace Physiology,the Fourth Military Medical University,Xi'an 710032,China) |
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| Abstract: | Objective: Muscle contraction may prompt glucose uptake through non-insulin-dependent ways,and it may be due to the enhanced activation of key proteins known to regulate glucose metabolism,like p38 and Akt.Our experiment focused on the impact of different contraction modes on the phosphorylation of the molecules,thus to explore effective ways to lower blood glucose.Methods: Isolated muscle strips perfusion technique and Western blot analysis were employed to investigate the influence of different modes of c... |
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| Keywords: | tetanic contraction p38 Akt glucose uptake |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
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