| 通心络对低氧预适应小鼠神经元超微结构及内皮细胞自修复能力的影响 |
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| 作者姓名： | Wu XC Lai J Wu XF Jia ZH Wei C Wang HT |
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| 作者单位： | 河北以岭医药研究院;河北以岭医院;石家庄市第三医院; |
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| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目(2005CB523301); 国家十一五“重大新药创制项目”:络病理论指导药物开发集成创新技术平台建设(009ZX09313-003) |
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| 摘 要： | 目的：观察低氧预适应对小鼠脑皮层神经元和内皮细胞超微结构的改变及通心络的作用。方法：40只小鼠随机分为正常对照组、低氧组、低氧预适应组和通心络组（低氧预适应＋通心络）,利用重复低氧5次复制低氧预适应小鼠模型后,记录小鼠每次低氧耐受的时间,观察脑皮层神经元和血管内皮细胞超微结构的改变。结果：随着低氧次数的增加,预适应组和通心络组小鼠耐受时间增加（P〈0．05或P〈0．01）。与预适应组比较,通心络组小鼠耐受时间增加（P〈0．05或P〈0．01）;低氧组小鼠脑皮层内皮细胞和神经元超微结构发生明显改变,预适应组小鼠脑组织神经元及血管内皮细胞超微结构改善,通心络组脑组织神经元及血管内皮细胞超微结构明显改善。结论：低氧预适应显示出机体具有强大的自修复能力,通心络能明显增强机体的自修复能力,提高自适应。
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| 关 键 词： | 低氧预适应 通心络 自修复 神经元 内皮细胞 |
Effects of Tongxinluo on neuron ultrastructure and endothelial cell self-repairing ability in hypoxia preconditioning mice |
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| Wu XC,Lai J,Wu XF,Jia ZH,Wei C,Wang HT.Effects of Tongxinluo on neuron ultrastructure and endothelial cell self-repairing ability in hypoxia preconditioning mice[J].Chinese Journal of Applied Physiology,2011,27(4):396-399. |
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| Authors: | Wu Xiang-Chun Lai Jing Wu Xiang-Feng Jia Zhen-Hua Wei Cong Wang Hong-Tao |
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| Institution: | WU Xiang-chun1,2,LAI Jing3,WU Xiang-feng2,JIA Zhen-hua1,WEI Cong1,WANG Hong-tao1(1.Hebei Yiling Pharmaceutical Research Institute,Shijiazhuang 050035,2.Hebei Yiling Hospital,Shijiazhuang 050091,China,3.The Third Hospital of Shijiazhuang City,Shijiazhuang 050017,China) |
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| Abstract: | Objective: To observe the ultrastructure changes of cerebral cortex neuron and endothelial cell in hypoxia preconditioning mice and the effects of Tongxinluo(TXL,Chinese traditional medilihe)on them.Methods: Mice were randomly divided into 4 groups: control group,hypoxia group,hypoxia preconditioning(HP) group and Tongxinluo(TXL)group.The hypoxia preconditioning mice were exposed by repetitive hypoxia for 5 runs.The animal's tolerance time of each hypoxia run was recorded.The ultrastructure change of cerebr... |
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| Keywords: | hypoxia preconditioning Tongxinluo self-reparing neuron endothelial cell |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
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