| MPO129A／G基因多态性与冠心病严重程度相关研究 |
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| 作者姓名： | Hu JL Xu JB Zhou X Jiang TM Li YM Zhang M |
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| 作者单位： | 天津医科大学研究生院;中国人民武装警察部队医学院附属医院心内科; |
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| 基金项目： | 天津市自然科学基金课题资助(09JCYBJC11900) |
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| 摘 要： | 目的：探讨髓过氧化物酶129A／G基因多态性与冠心病严重程度关系。方法：入选住院冠心病患者267例,均行冠脉造影检查。用比色法测定血清髓过氧化物酶活性;用聚合酶链反应．限制性片段长度多态性（PCR-RFLP）确定各研究对象的基因型。根据冠脉造影结果分别采用冠脉病变支数和Gensini评分来评估冠心病严重程度。结果：MPO129位点A、G等位基因频率分别为0．107和0．893。不同基因型组间血清髓过氧化物酶活性无明显差异,不同基因型在Gensini评分组间的分布无明显差异,基因型GG患者冠脉病变倾向于多血管病变。结论：髓过氧化物酶129A／G基因多态性与血清髓过氧化物酶活性无显著相关,其不能作为预测冠心病病变严重程度的理想指标。
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| 关 键 词： | 髓过氧化物酶 基因多态性 冠心病 Gemini’评分 |
Correlation between MPO 129 A/G polymorphism and severity of coronary artery disease |
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| Hu JL,Xu JB,Zhou X,Jiang TM,Li YM,Zhang M.Correlation between MPO 129 A/G polymorphism and severity of coronary artery disease[J].Chinese Journal of Applied Physiology,2011,27(3):306-310. |
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| Authors: | Hu Jun-ling Xu Jian-bo Zhou Xin Jiang Tie-min Li Yu-ming Zhang Mei |
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| Institution: | HU Jun-ling1,2,XU Jian-bo2,ZHOU Xin2,JIANG Tie-min2,LI Yu-ming2,ZHANG Mei2(1.Graduate School of Tianjin Medical University,Tianjin 300070,2.Department of Cardiology,The Affiliated Hospital of Medical College of Chinese People's Armed Police Forces,Tianjin 300162,China) |
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| Abstract: | Objective:To explore the relationship between myeloperoxidase(MPO) 129 A/G promoter polymorphisms and the severity of coronary artery disease(CAD).Methods: The study enrolled 267 patients who had been diagnosed as coronary artery diseases by coronary angiography.The serum MPO activity was detected by colorimetric method.PCR-RFLP method was used to decide the genotypes of the patients.The severity of CAD was evaluated by the numbers of stenotic coronary arteries and the Gensini scores respectively.Results: T... |
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| Keywords: | myeloperoxidase polymorphism coronary artery disease Gensini Score |
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